You must have been using a version of Backup Exec older than 2010 R3 as we have NOT allowed renaming of the B2D location (or putting multiple B2Ds on one disk volume) through 4 versions.
Basically what you need to do (assuming USB disks) is
Create a single backup to disk storage device on each USB disk
Create a drive pool and add each USB disk to it (you can add later disks to it as needed)
Target the jobs to the drive pool and BE will use whichever disk is connected at the time (so make sure only 1 disk is connected)
You cannot have separate Differential and Full folders (in fact there was no real point in doing that with the older versions either as they still depended on the full in a DR situation) and if you write a second week to the same disk it also has to use the same structure.
Finally make sure thet the differential sets are always on the same disk as the full set they are linked to as GRT restores and/or point in time restores will have issues if the chain back to the full is on disks that are not online
If using RDX carttridges, you don't use a drive pool and you configure the RDX drive as Removable Storage but otherwise the principle remains the same in taht you cannot specify the folders within the disks.
A BIG WARNING - you need to read up on DLM and how retention times now work as BE will now try to erase older sets behind the scenes as long as the data is beyond the retention - with USB and RDX this ONLY happens when the disks are online and there is a default setting so that any USB disk that is offline for longer than 2 weeks and any RDX disk that is offline for 4 weeks will be write protected for you to avoid mishaps against long term vaulted sets.