Backup Exec Compression Settings Questions

Hi, i'm trying to figure out the best method when compressing data using Backup Exec.  I currently backup my servers to disk using remote agents and then I run a duplicate job to tape (LTO5).  I am running BE 2014 and the data is a mix of everything from file servers to sql, ad and exchange databases to hyper-v vm's.  My questions are:

-Should I run software compression when doing the initial backup to disk and then no compression on the duplicate to tape? 

-Should I run no compression for the inital backup and then hardware compression to tape?  This is how i'm currently doing things but disk space is slowly becoming a concern and i'm starting to question why it was ever set up this way.

I found that compressing both times is not a good idea according to: "Data that has already been compressed or random data (such as encrypted data or MPEG files) may actually expand by about five percent when attempting to compress it further. This can reduce drive throughput." http://www.symantec.com/business/support/index?page=content&id=TECH49521) 

I did read somewhere that the compression ratio between hardware and software compression are almost equal. 

I also read that the only disadvantage to software compression is: "Depending on your environment some system overhead might be involved. However, it’s quite negligible." http://www.symantec.com/connect/articles/understanding-compression-backup-exec.  pkh asked in that thread on April 12, 2014: "If this is true, why would one want to use hardware compression?" It was never answered and i'm hoping to find an answer or at least find what is considered a best practice.  The only answer I can think of is if you backup direct to tape. 

One last note, encryption is not involved.  I understand "if you require both encryption and compression, then both have to be software to achieve any compression.  The data is compressed and then encrypted on the server" according to: https://www-secure.symantec.com/connect/articles/compression-short-explanation.

Thanks in advance.