AFE = Active File Exclusion
Backup Exec uses the Active File Exclusion feature to eliminate the Microsoft Exchange Server, the SQL Server, the Share Point Portal Server, and the Lotus Notes/Domino flat-files from the file system backup. This will prevent "in use - skipped" errors on the .EDB, the .STM, and the .LOG files. In some cases backups may run for a few seconds then appear to complete with only 1k of data with no error messages. The Active File Exclusion feature also prevents .EXE files registered as Services from being backed up as part of the file system backup since those files are part of the System State backup.
http://www.symantec.com/docs/TECH23574 - Why do some files under the MDBDATA folder not appear in the restore selection interface even after a successful backup of the MDBDATA folder?
"Backup Exec 9.x, 10.x,11.x,12.x, 2010 for Windows Servers uses the Active File Exclusion feature to exclude the Microsoft Exchange Server flat-files from the file system backup. This prevents the "in use - skipped" errors on the .edb, the .stm, and the .log files."