my understnding says.. needs to install client software and configure the DB agent..(i could be wrong)..
extracted form Netbackup for VmWare admin guide page 16
About the virtual machine backups that include database data
When NetBackup backs up a VMware virtual machine, database data in the virtual
machine is backed up with the rest of the virtual machine. A new feature in
NetBackup 7.5 allows the recovery of individual database files from the backup.
This feature supports Microsoft Exchange Server, SQL Server, and SharePoint
Server.
Note the following:
■ To enable restore of individual database files, a NetBackup Windows client
must be installed in the virtual machine during the backup.
■ NetBackup uses Windows Volume Shadow Copy Service (VSS) to quiesce the
database before it creates a snapshot of the virtual machine.
■ A full backup is performed of the database data with each backup job, even if
the policy schedule is incremental.