I'm running BUE 16 and attempting to back up a Server 2016 VM (vSphere 6.0 U3) and it always fails with 0xe0009582-Cannot get the disk changed information. I have two other 2016 VMs that are backing up fine. The only difference with this one is that it has an independent disk attached, which, if memory servers are automatically excluded during backup. I've uninstalled/reinstalled the agent, insured the VSS provider is not installed in VMware tools, and tried several jobs with instant GRT, VM GRT, and Advanced Open File option enabled and disabled. Nothing has worked so far. Any ideas?
First please take a look at this article: https://www.veritas.com/support/en_US/article.TECH66007
You may also want to try resetting the CBT for that VM: https://www.veritas.com/support/en_US/article.100027732.html
I would also try manually excluding/detaching the independant disk you suspect is the issue in a test job for just that VM to see if that is the issue.
You may also want to see if a Windows agent backup is successful on that VM or if it errors.