The Administrator's Guide says, "Because of a Microsoft Exchange limitation, snapshot and traditional backups are not interoperable when restoring Exchange data. Therefore, if traditional (non-snapshot) backups are performed as part of a data protection scheme, then snapshot backups should not be performed. Also, if snapshot backups are
performed, traditional backups should not be done."
Basically it says it'll work, but you'll have problems restoring if you also use non-AOFO backups.
If you were just reading the guide, this probably wouldn't mean anything to you.