Do not seem to get along. 12.5 did.
The 2010 SCL says yes (and maybe), and BE2010 says:
e0000f20 - Backup operations for Exchange Server 2000 are not supported by this version of Backup Exec. Remove the resource or resources from the selection list. Edit the selection list properties, click the View Selection Details tab, and then remove the resource.
For additional information regarding this error refer to link
V-79-57344-3872
neither the error or the link exist in the support db.
Have tried file, drive (C: and M:) all get the same result.
Bottom line is, I suppose, no.
Am I missing an option? Media server WS2008 x64, target is SBS2000.