Incase some desktops are static (not a remote users) then you backup them just like any other remote machine just by installing the remote agent and purchase the DLO for those systems which are remotely connected from time to time so they can benefit from DLO by synchroising offline files and folders during backup.
Alternatively, desktop userswith full access to the Desktop Agent interface can schedule backups, select which typesof files to back up, restore files, synchronize file versions between different computers,and view the status of their backups.