How does 6TB of jpeg's ranging from 100KB-600KB in size work for you?
These were spread across three 2TB LUN's on a Windows powered NAS (HP StorageWorks server)
That said, BE cannot do it natively well unless you want a backup window measured in days to a week... You have two options. both pretty ugly but workable.
1. BackupExec System Recovery. It takes a block level backup of the disk, so it'll be faster. But it's a separate product with no integration to BackupExec. So you'll have to manage this as a one-off backup, and script in the advanced functions a post-command to call BackupExec to backup your recovery point.
2. Use Storage Foundation with FlashSnap, which does integrate with BackupExec, but it's also sold as a separate product. It will create a mirror snapshot, but backup the partition as a RAW volume, ignoring the filesystem. But still give you the ability to restore individual files. You will have to double your storage! Also since it's a RAW partition backup, if you had a 10TB volume, with only 6TB consumed, your backup will be 10TB. So you need to better manage your disk and growth strategy.