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Nope, this isn't possible. You should ensure that your append/overwrite protection settings are correct so that the RDX cartridge is ready for use when the job runs.
Otherwise you need to be happy with manually erasing the tape each night before the backup runs.
An RDX Cartridge is a disk, not a tape. Therefore there is no "erase job" for it, rather you would go delete backup sets (using BE GUI, Storage tab). There are not append/overwrite settings for disk cartridge, you simply set the amount of time the data should be retained.