As far as live databases supported by Backup Exec is concerned, you will not need to add any exclusions as there is active file exclusion, handled automatically by Backup Exec, as long you are protecting those files using BE agent. Also, Operating system takes care of some exclusions. So, you do not backup any database files known to Backup Exec, unless you have some specific database application which BE is not aware of. So, there would be hardly a requirement to exclude any other files or folders.
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