Jane,
I'm not sure how you classify a large company, for comparison we have about 15-16,000 archives in our EV environment and somewhere just over 100 cases (active, closed, or otherwise) in DA. We actually engaged consulting in the design of our environment, and for each customer database they specified 50 gigs for log drive and 100 gigs for database. This was WAY too small. Our database cruises right now at around 140 gigs, and during reindexing (which I need to do CONSTANTLY to keep the indexes in shape..they recommend weekly) it can grow to 220gb+. I had log backups running every 20 minutes to make sure my 50 gig log drive didn't fill up.
I have expanded my database drive to 400 gigs and my log drive to 150 gigs. Things seem to be happy now. As Liam said, RAID10 is a must. DA just crushes SQL.
Be sure when setting it up that you follow the best practices for routine SQL maintenance for DA, per the following technote.
Routine monitoring and maintenance for the Accelerator environment - http://support.veritas.com/docs/308418