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Symantec Messaging Gateway adding additional Domain to Exchange 2010.


My question is that i have to add an addition domain to my Exchange 2010. I am fairly familiar with the process on how to add that. i am using symanted messaging gateway which routes SMTP traffic to my exchange 2010 server and one domain is currently running fine that can send and receive email. Now if I add another domain. Will i need to make changes within the Symantec messaging gateway. What are the things that i need to keep in mind before going ahead with the project.