It depends on the appliance and what you have configured it for. If you just enabled Fibre Transport then any port on any fibre card can be used for zoning to data stores or tape or 5020. If you enabled Fibre Transport and SAN client then not all ports can be used. Look at the following guide on page 184 and 185. This is the latest appliance guide.
i 'm aware of port bindings in appliance. question was does datastore zoning requires ESX to be mediate or should be one to one with appliance
datastore are alreay zoned to ESX, VMware and Storage guy are keen to minimize scope involved by limiting zoning to esx only.instead of datastore.
more over datastores are using DMP for redundacy... so how zoning would take place in such scenario...
Datastore must be zoned to Appliance - same pricipal as with Windows backup host.
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When you asked "Also how to identify slot and port # from back side panel of appliance" I asumed you wanted an answer. If so then that is in the manual.
You cannot zone to an ESX host you can only backup via IP from the ESX host. You should only zone one path from the 5220 to the data store as there is a bug in the ESX code that prevents Linux hosts from creating a multipath configuration.
You would zone as many Data stores as you feel you can backup in a window to the 5220. That number will depend on how many guests are on the volume and how much other traffic the 5220 handles.But it is much more than 1:1 datastore to appliance.