Doing a backup on a different NIC is a good consideration, but also consider putting that backup data on a VLAN back to the Master Server, so it is entirely segragated from the production LAN.
We have that setup.
For example:
Server hostname: fred (NIC#1)
NetBackup hostname: fred-b (NIC#2)
So any reference in NetBackup we use the fred-b hostname as the client. We also maintain local hosts file entries for this client and the master server which also has a VLAN IP address.