Don't activate the TIR (True Image Restore) option in a policy containing Distributed File System Replication folders. The result will be incremental backup with same size as the full backup.
As the target is a subset of Shadow Copy Components, Microsoft DFSR writer is used to access the data (i.e. Netbackup tells DFSR writer what to backup and waits for it to return the data). However the DFSR VSS writer is TIR unaware.
TIR will however function at a file system level as designed, but for DFSR data this would require DFSR service to be stopped for correct functionality.
The TIR option will not be greyed out in the policy as the policy type for the backup is MS-Windows-NT which otherwise supports TIR.