From the notes that I took at a Symantec presentation:
CPU > 2.2 Ghz
min 4 cores - prefer 8 cores
min 4 GB RAM
- need roughly 1 GB RAM per 1 TB back-end.
- e.g. with 8TB pool, you should get at least 8 GB RAM
In general, for media servers, you need a server capable of high I/O but the de-dupe adds the high CPU requirement. Consider PCI express a must. More RAM is always good. Masters servers are the reverse - they require more CPU than I/O.
Something along the lines of an HP DL585 G5 or a Sun T5240 is good. For de-dupe media servers, an Intel architecture is preferable to the T5000 series.