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@rob, there's a reason why people use a DataDomain over JBOD....it's called deduplication. But, if you are going to use that at your primary and remote site you have to be aware of the expense. And, in CraigV's case, it sounds like the customer is more than willing to cover that.
Cost should be a factor in the discussion. You should be able to determine the cost of having key applications down for an extended period. That will give you an idea just how expensive the data protection solution should be. If you don't take cost into consideration, then every application in your company will say that they absolutely need the highest level of protection and that's just asking for trouble.
Still, just having the data replicated from one site to another is only part of the solution. The other part (the harder part) is being able to recover from a disaster at your primary site. If you don't have those details covered up front, then it will all be for nothing.