file exclusions for MS Exchange 2013 clients

Environment:

NetBackup Client v7.7.3 on Windows Server 2012 R2 with MS Exchange Server 2013 CU13 in a four node DAG with four node CAS.

NetBackup Master/Media Server v7.7.3 on Appliance 5230 v2.7.3.

Backup type: plain NTFS volume\folder\file style backup (we are already excluding the live mailbox database files)

.

Situation:

I have found a folder on disk, and therefore in backups:

D:\Program Files\Microsoft\Exchange server\V15\TransportRoles\data\Queue

...which contains a 24GB "mail.que" file and a small "tmp.edb" file and a small "trn.log" file, and a few other related files... which altogether appear to be some form of quasi live binary database/application file set... which typically one might ordinarily consider excluding from backups.

There are also, other folders:

D:\Program Files\Microsoft\Exchange server\V15\TransportRoles\Logs    at 2.3 GB

...and...

D:\Program Files\Microsoft\Exchange server\V15\Logging        at 12.5 GB

.

Question:

Is it typical, and/or best practice, and/or even required, that these days with MS Exchange 2013 we can/should/must exclude any of these three paths from regular file system backups?

D:\Program Files\Microsoft\Exchange server\V15\TransportRoles\data

D:\Program Files\Microsoft\Exchange server\V15\TransportRoles\Logs

D:\Program Files\Microsoft\Exchange server\V15\Logging

.

Thanks in advance.