Upgrade Vshpere4.0 to Vshpere5.0 - Affect on BE 2010 R2 Vmware agent

all, its been couple of years since i last used be 12.5, on to the new job and its be2010r2 being used to backu vshpere 4.0 inf. (200) servers. i would like to upgrade vshpere 4.0 to 5.0? do i ne...