Old thread but it is still valid. Unfortunately the whole topic is poorly documented from NetBackup side.
First of all the posted video is not only confusing for first sight but in fact it is very misleading. The person who created the drawing on the white board should have at least checked some basic details with his colleagues before putting it into the public. Clearly this video is more about the NBU intelligent policies rather than anything related to VMware VSAN compatibility in general. Generally speaking VSAN and SAN transport are two completely different things and are absolutely incompatible with each other. VSAN as a name is valid just from marketing point of view but in fact it has nothing to do with true SAN infrastructure. Furthermore if you don't particularly work with SAN Transport in NBU you wouldn't even know where to find the hidden details about what is going to work at all and what is to be abandoned at the conceptual level.
So long story short - SAN transport is not only NOT compatible with VMware VSAN but actually it is disabled by default whenever VSAN is detected on a particular host. At the moment you just can't use any combination of the two technologies and this is due to the limitations set in the VDDK. Check out the following link for more details:
https://pubs.vmware.com/vsphere-6-5/index.jsp?topic=%2Fcom.vmware.vddk.pg.doc%2FvddkDataStruct.5.5.html
Not that we could blame this onto NBU but the product is using an external framework for its tighter integration and therefore NBU should have at least had this limitation outlined in the release notes. I had to figure it out myself the hard way after realizing that my already built SAN Transport is not working anymore. For me NBU was constantly reporting back with "ERR - Error opening the snapshot disks using given transport mode: san Status 23" messages and it took me quite some time to realize what was going on due to the very ambiguous output data generated at the highest log verbosity.
Anyway... lesson learnt, don't take anything for granted even though there are no initial signs of either incompatibilities or limitations. While the release notes weren't mentioning anything about my particular situation I still managed to fall into the trap quite successfully yet I can still feel somewhat lucky that in my case it was an enlightenment from troubleshooting experience rather than a dumb implementation caused by a misleading video (and to be clear I blame the vendor for this...).
I have another similar example with information hidden in the VDDK which is from almost a decade ago when I first tried to implement iSCSI SAN based Transport for my VMware environment (I think it was VCB at the time being). Everything was fine till the point I tried it onto a virtualized NBU media server. While technically this solution should work, the VDDK limitations are pretty much clear on the mandatory requirement for a physical host. The ultimate result was just a whole bunch of NBU error messages but once again without clear statement from the vendor on why is that. Obviously those limitations are set on purpose not because of real technical incompatibilities but due to the lack of enough testing scenarios and most probably marketing departments had their own share for setting the margins but all in all the lack of clear statement is absolutely inexcusable.
Anyway just for the record I'm currently using NetBackup 8.0 with VMware vSphere 6.5 + VSAN 6.6.