Hi William,
I cannot say that I have seen this issue before. However, I looked at your screenshot, and you have the DVD browser running, and it looks like a white screen. This is a dialog that should have main.htm content loaded inside it. Since you are getting a prompt to save "Main.htm", I would gather that something has changed in your IE configuration preventing us from loading the web content, or there is a problem with the registration of Internet Explorer files on your system.
If so, this can cause issues for our install as it uses Internet Explorer integration in the OS to create items like our log files, install summary pages and such. There is an existing technote which may help get these items reregistered, though its for a different issue. Here is the technote I am referring to:
http://www.symantec.com/business/support/index?page=content&id=TECH140831
You may want to reach out to our support department for help with this issue. It is difficult to ascertain if this is the problem, or a symptom of another issue from just a screen shot.
Hope this helps,
Nick