Greg,
If you perform infinate appends, and don't choose to overwrite your media, you could end up in a bigger mess than you started out with.
If you always append, every piece of media you use will then be part of that "family". That means if your server goes down, and you have to reinventory/catlog your media you may be asked for media that doesn't even exist, because Backup Exec konws they are part of the tape family. This is why its strongly recommended to start new families, and the only way to do that is by choose the option "Overwrite media", instead of "Append to media, overwrite if no appendable medai is available".
Second, if you have very large B2D files (like 500GB per sea, there is a good chance that will never be overwritten. When a backup is run, and it uses that single piece of media, the software isn't smart enough to overwrite the older sets within that file. It looks for additional media only.
Third, you can set it up such that you only have x amount of media in your B2D folder. To do this, it will take a little big of configuring and some math.
For example, we'll use your Exchnage backup for an example. You would need to configure your Backup To Disk folder to "Allocate the maximum size for backup-to-disk files". I would configure the maximum size for B2D files to ~80GB, the size of your database. This will then only create 6 - 80GB files for your backups.
However, it's not recommended to use that large of a file, only because Windows SMB has been known to have problems with very large files. But that is one scenario in which you can control how many files are created.