I have no doubt that by excluding the Downloads folder the backup job will run fine. What I am concerned with is restoring the data that didn't get backed up because this folder did not get backed up. By excluding that folder, not only will the temporary sub-folders be excluded but also the other files in the Downloads folder and the Downloads folder itself will be excluded.
Should I infer from your suggestion to exclude the Downloads folder that you *know for sure* that this particular application will run fine after a disaster recovery without the Downloads folder being restored, that is, SAV CE needs nothing in that folder (the whole folder (not just the dynamically named sub-folders) is for just temporary use) and will recreate the folder if it does not exist? Since the folder is from a Symantec application, maybe you have special insight into the needs for a disaster recovery for this application, or maybe you have some practical experience doing a disaster recovery with this application that lead you to suggest just excluding the entire Downloads folder. My experience with disaster recovery (restore form bare metal) is that the folders that were excluded during normal backups (usually because they are always in use and can't be backed up) caused huge problems. (In fact, at one customer site, I was there for 17 hours straight with three engineers from Veritas and two from Microsoft on the phone trying to restore/recreate the files/folders that had been excluded during the backup process and therefore not restored after the disaster.) So, I am not caviler in excluding folders from the backup job.
I also assume from your response that there is no way to specify an exclusion of the dynamically named sub-folders in the Downloads folder but include the files and the Downloads folder itself. Is that correct?