I am getting successful Exchange 2007 backups (no easy task) but the backup job is skipping these files on the C drive. I assume it's ok that these files are skipped:
C:\Program Files\Microsoft\Exchange Server\TransportRoles\data\IpFilter\
IpFiltering.edb
tmp.edb
trn.log
C:\Program Files\Microsoft\Exchange Server\TransportRoles\data\Queue\
mail.que
tmp.edb
trn.log
trntmp.log