This is and issue that has been going on for a little while and has recently seemed to have gotten worse.
I have a windows 2K3 SE SP1 running Exchange 2k3 sp2. Backup runs using the exchange agent and windows remote agent. Backup and media server is a windows 2K domain controller. Backup type is a backup to disk and the disk is an external disk appliance. I run a full backup (including mailbox backup) on the exchange server nightly at 2AM (including weekends). The backups run fine until it gets to the mailbox backups. It will typically fail between 5:30 AM and 7:30AM but never in the same mailbox. Backup if failing because something is taking the information store down. Then I get the communication error in backup exec.
What is interesting is the backup runs fine over the weekends no problems at all, but come monday morning it will have failed. It seems to have something to do when there are users on the system, as some of my users get in an check email at 6:30AM. However, I do not know why this would be the case.
I do have Panda Exchange Secure on the server and it is still enabled during the backup.
Any information would be great.