Yes, WAN optimization should help. HOWTO94262 gives the benefits of WAN Optimization:
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Beneficial for appliances for which the traffic is sent across on slower networks. Such as networks with a latency greater than 20 milliseconds and packet loss rates greater than 0.01% (1 in 10,0000).
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Operates on individual TCP connections. Evaluates each outbound network connection to determine whether the performance can be improved.
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Improves the network performance with minimal dependency on the outbound network traffic.
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Improves the network performance of optimized duplications.
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Improves the network performance of restores to remote clients.
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WAN optimization is non-intrusive, it does not impose any overhead in situations where the overall network traffic is already high. In some scenarios, when the overall network traffic is higher, the connection speed may not be optimized despite of this feature being enabled. In such situations the WAN Optimization is bypassed and it is not recorded in the traffic command optimized data per second report.
