Question 1 - Yes correct, for OST you can use a 32bit OS. However, in order to get OST, you have to buy the Dedupe option in BE2010. So you might as well as use a 64bit OS just to take advantage of client side dedupe just in case. No point in crippling yourself in the future if when you may need the client side dedupe.
Question 2 - DataDomain (DD) has not been officially certified their device and BE2010. Until the HCL is updated, you're on your own there... The HCL is updated about every two months, and the time line for DD to finish updating their OST plug-in for BE was the "end of March." So it should be on the HCL and working shortly me thinks... As of today, it is ONLY the companies you mentioned that have been supported via OST for BE2010. DD is not too far behind... Of course you need to verify 64bit certification from DD and their plug-in as they are having an issue with that.