Hi,
Depends on what you want to do, how much data you're backing up, what type of device you're backing up too as well.
If you have an autoloader/library, consider partitioning the slots, and assigning the jobs to those slots. It means you know where the tapes go, and allows for better organising.
Depending on the size of your backups and the size of your tapes, you can look at doing FULL backups too. It would mean less tapes being used when restoring.
Use the Symantec drivers, and disable Removable Storage Service if you have any Windows OS lower than 2008.
You didn't mention your version of Backup Exec, but you can also look at downloading the Admin Guide for your particular version. It will also clue you in a bit.
That is about it...