If you are absolutely certain that you want to write to whatever drive is connected (even if it's last night's drive that was never swapped out
Go to Tools\Media Management and select None as opposed to Partial or Full Also select "Do Not Prompt when overwriting ..." or whatever the wording is
With these set, BackupExec SHOULD do what you want
Personally, if the drives are big enough for more that one backup, I'd set media set OPP to 24 hrs, and the Global management to "Partial". That way if you (or your vacation replacement) forgets to swap drives, you still have at least two days of backups