Certainly
Reserve a drive letter for each drive (you can remove drives, but not swap drives).
Create a B2D folder on each disk, and make sure that you mount the drive on the same letter each time it is connected (use Disk Manager to assign a drive letter to do this)
put both B2D folders in a Drive pool, and point your job at that pool
When you swap drives, pause/unpause the folders to refresh the BackupExec device list