Running BE 11d on a Windows 2000 server using a dual LTO-3 drive Overland Neo 2000 via iSCSI. 20 servers backed up full over the weekend, differential each week night.
Worked like a charm for three months, then on Friday 7/27 early morning, backups started failing with "hardware error" messages. Cleaned drives, no effect. Rebooted everything, no effect. Disconnected iSCSI, reconfigured the connection, no effect.
Ultimately, discovered that the failures seemed to happen when tapes were loaded in both drives (even if one was inactive), so disabled one drive in the Overland and backups started working again. Doesn't matter which drive is disabled, so it's unlikely to be an actual "hardware" problem. Library Expansion Option is licensed and the license is installed (obviously, since it worked for 3 months). No other tape drives configured. Ran Tools/License Keys and Installation again to try to kick-start the LE Option, no effect.
Solution? Other than wiping, reinstalling (including all the Option licenses), and rebuilding all 40 backup jobs from scratch?