Hello,
Are you using the Advanced open file option during backup? Refer to the steps below:
1) Try to Backup System State via NT backup. ( Stop all the Backup Exec services while performing NT backup ). Revert with the result of the same with NT job log.
2) If this server is not hosting any mission critical databases or if this is not a production server, you can re-boot the system and then try to Backup System State via Backup Exec. Revert with the results.
3) Also for test purpose, stop the Anti virus service on the remote server during backup and test the results.
We hope this helps.If issue persists, do update with details.
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Regards.