I actually cannot see any reason why not though I have never attempted this myself. The OVEnabled reg key will still be set, the resetofflinevault file will only be created if the reset offline vault button is selected therefore there is no reason for the wizard to believe that it has to run again and therefore I believe offline vault will work as the shortcuts will all match up with the data in offline vault.
Why not test it quickly between two machines you have? If it works burn it and send it to the user. The offline vault data is stored in a KVS folder within the users profile by default under the hidden folder local settings I believe and a few sub-folders.