I explored using RAID to create a super volume on our SAN for backup, but then decided to create a Storage Group. NBU will then backup up to all of our 2TB disks, but if one of them has a problem I can remove it from the group or add more with little problem. The load balancing isn't as perfect as with RAID, but it's does seem to write each job to a different disk, spreading out the load.
We were worried about fragmentation problems on the RAID. It is easier for Diskeeper to defrag several smaller drives that one massive drive.