Limited testing hasn't shown any major problems, but need more time/different tape drive types to verify. Did you happen to notice that this SP does NOT include:
10.1.5629 Hotfix 9 - Installation of hotfixes can overwrite RAWS.msp and large handle leak in beremote.exe when backing up data on an MSCS cluster.
Still more quality control at work, oh well at least HF20 wasn't included in the SP, then things would have really been messed up..