I've found something odd and wanted to reach out to see if there's any experience in fixing this...
One user logs into his workstation as a local account, then does a runas to open his mailbox under his domain account.The only button on the EVClient which works in this configuration is the "Search Vaults" button - as if the user account has not been enabled. This is also true (i.e. it does not work) if the user logs on to the workstation with his domain account.
However if the user logs into his local account on his workstation and runs Outlook under this local account the client works.
Other users in the same environment who login with their domain account and run Outlook under their domain account are working.
This seems to be isolated to one user but I'd really like to know what's going on.