With BE2010, and the AVVI agent, you can backup the VMDK itself, and the agent within the guest will quiesce the Db, commit any transaction logs, and then VMware will snap the VMDK. But the overall backup duties will be 95% handled by vcenter, the last 5% is for the agent to use VSS and collect any additional meta data.
You will get much higher throughput this way by NOT using an agent to do the backup duties.