Enterprise Vault will easily run against all four domains that you want to add (for instance with the company that i work for we have some EV sites targeting 6 or 7 domains).
Your biggest concern is probably going to be duplicate mailboxes, because Enterprise Vault determines things such as LegacyMbxDN as to whether this is a new mailbox or an existing mailbox, and most likely when you go to Exchange 2010 you will end up with EV seeing this as a new mailb ox and create a new archive.
I would strongly suggest trying to configure a multi domain environment within VMWare and test the different scenarios yourself as you don't want it to get to the crunch time and not being quite too certain with how this will all work out in the end.
Also would suggest engaging Symantec or one of the partners to see if they can help you design a migration strategy should it be needed.
But really you should be ok with the target EV server in your own domain, you just may need to expand the amount of servers due to the extra load you will be bringing on
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