I would check on acsls side if drive is in available state - query drive all - and search for Your drive.
If there drive is in available state, check the FC zonning, is drive still logged to fabric, is your FC HBA to see the drive??
Check if acsls server is responidng to ping from You master server.
If it is, then check on OS lvl if drive is still there. Try to recreate device special files for this drive (under UNIX) on windows remove it and rediscover. Once this is done - stop ltid daemon with stopltid command and run it with ltid command. All Your running jobs will fail at that time.
Check also this doc: http://seer.entsupport.symantec.com/docs/267306.htm