There is very little you can do. Compression is turned on or off, you cannot select which files or directories to compress. What might make a differance is if you use sofware or hardware compression, either way trying to compress an compressed file wil not work and because this will be tried it might take some more time to get those files onto the backup tape.
If your diskspace allows it you could try to use uncompressed cad files and see if this makes a differance in backup time.
Kind reagards
A van der Boom