Bruce
I think the AMS 2500 is no different than other storage.
You need to get the I/O's trough, and have enough space.
I personally would not do "mega LUNS" (sounds like very big luns... > 2 TB?) because, think about what happens when Windows does a checkdisk on it... You will be down for hours!
Instead, create multiple smaller ones (I think about 500 GB?), and create Vault Store Partitions to distribute the content.
Just my 5 cents.
Cheers
Michel