Nathan,
This is all configured on the master server.
I believe you will be OK disabling OFB. The important Exchange stuff should be backed up via the Exchange Agent. Check these tech notes out in regards to setting up Exchange Backups (these are for 5.0/5.1, as I wasn't sure what version you're using):
DOCUMENTATION: How to configure Veritas NetBackup (tm) for Exchange 5.5 and 2000/2003 database backups: http://support.veritas.com/docs/276496
Configuration of mailbox backups for Exchange 2000/2003 using NetBackup 5.0/5.1: http://seer.entsupport.symantec.com/docs/275182.htm
In terms of how to turn off OFB, it's pretty easy:
On you master server, go to the 'Host Properties' section and expand it.
Select Master Server
Double-Click on the appropriate master listed on the right.
In the window that pops up, go to the 'Client Attributes' section.
You'll see a window on the right where some hosts may (or may not) be listed.
Click the 'Add' button.
What you need to do is make an entry that matches the exact name of the client you want to turn OFB off on (ex: if you use 'servername.domain.com' as the client name, you'll need to add that in identically).
After you add the client entry, click on the 'Windows Open File Backup' tab.
UNCHECK 'Enable Windows Open File Backup for this client'
Close out of this window.
You will be prompted that you need to restart your services, but that is not absolutely necessary (though it is a good idea if you're able to do so).
Hope that helps!
